General Information of the Compound
Compound ID
CP0894465
Compound Name
5-(5-((4-amino-2-(methylsulfinyl)pyrimidin-5-yl)methoxy)-2-bromo-3-fluoro-4-hydroxybenzylidene)-3-methylthiazolidine-2,4-dione
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Structure
Formula
C17H14BrFN4O5S2
Molecular Weight
517.358
Canonical SMILES
CN1C(=O)S/C(=C\c2cc(OCc3cnc([S+](C)[O-])nc3N)c(O)c(F)c2Br)C1=O
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InChI
InChI=1S/C17H14BrFN4O5S2/c1-23-15(25)10(29-17(23)26)4-7-3-9(13(24)12(19)11(7)18)28-6-8-5-21-16(30(2)27)22-14(8)20/h3-5,24H,6H2,1-2H3,(H2,20,21,22)/b10-4-
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InChIKey
KWEHAYWDKMUVMN-WMZJFQQLSA-N
Physicochemical Property
logP
2.6485
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
141.7
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 140896977
ChEMBL ID
CHEMBL4449511
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05581, Cyclic GMP-AMP synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 >= 10000 nM
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   LI
   LO
   TS