General Information of the Compound
Compound ID
CP0894458
Compound Name
5-(5-((4-amino-2-methylpyrimidin-5-yl)methoxy)-2-bromo-3-fluoro-4-hydroxybenzylidene)-3-methylthiophene-2,4(3H,5H)-dione
    Show/Hide
Structure
Formula
C18H15BrFN3O4S
Molecular Weight
468.304
Canonical SMILES
Cc1ncc(COc2cc(/C=C3\SC(=O)C(C)C3=O)c(Br)c(F)c2O)c(N)n1
    Show/Hide
InChI
InChI=1S/C18H15BrFN3O4S/c1-7-15(24)12(28-18(7)26)4-9-3-11(16(25)14(20)13(9)19)27-6-10-5-22-8(2)23-17(10)21/h3-5,7,25H,6H2,1-2H3,(H2,21,22,23)/b12-4-
    Show/Hide
InChIKey
VRGUFWUYONWIGG-QCDXTXTGSA-N
Physicochemical Property
logP
3.37292
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
115.4
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155562773
ChEMBL ID
CHEMBL4571733
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05581, Cyclic GMP-AMP synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS