General Information of the Compound
Compound ID
CP0894400
Compound Name
(2S)-2-amino-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1-(3-ethylpyrrolidin-1-yl)butane-1,4-dione bis(2,2,2-trifluoroacetate)
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Structure
Formula
C31H36F8N4O6
Molecular Weight
712.635
Canonical SMILES
CCC1CCN(C(=O)[C@@H](N)CC(=O)N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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InChI
InChI=1S/C27H34F2N4O2.2C2HF3O2/c1-2-19-11-12-33(18-19)27(35)24(30)17-25(34)31-13-15-32(16-14-31)26(20-3-7-22(28)8-4-20)21-5-9-23(29)10-6-21;2*3-2(4,5)1(6)7/h3-10,19,24,26H,2,11-18,30H2,1H3;2*(H,6,7)/t19?,24-;;/m0../s1
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InChIKey
CTQOOXZZUUWOGB-XCCUCOFDSA-N
Physicochemical Property
logP
4.4409
Rotatable Bonds
7
Heavy Atom Count
49
Polar Areas
144.48
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127047761
ChEMBL ID
CHEMBL3797358
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00975, Dipeptidyl peptidase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
Protein ID: PT03315, Prolyl endopeptidase FAP
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS