General Information of the Compound
Compound ID
CP0893657
Compound Name
4-Methyl-N-{[2-(2-methylpropyl)-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}benzamide
    Show/Hide
Structure
Formula
C22H28N2O
Molecular Weight
336.479
Canonical SMILES
Cc1ccc(C(=O)NCC2c3ccccc3CCN2CC(C)C)cc1
    Show/Hide
InChI
InChI=1S/C22H28N2O/c1-16(2)15-24-13-12-18-6-4-5-7-20(18)21(24)14-23-22(25)19-10-8-17(3)9-11-19/h4-11,16,21H,12-15H2,1-3H3,(H,23,25)
    Show/Hide
InChIKey
RMVRRMAGWIHRBV-UHFFFAOYSA-N
Physicochemical Property
logP
3.98022
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
32.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 137541811
ChEMBL ID
CHEMBL4089738
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS