General Information of the Compound
Compound ID
CP0893166
Compound Name
2-fluoro-N-(1,2,4-thiadiazol-5-yl)-4-(4-(5-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)benzenesulfonamide
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Structure
Formula
C23H18F4N6O4S2
Molecular Weight
582.561
Canonical SMILES
O=C(c1ccc(S(=O)(=O)Nc2ncns2)c(F)c1)N1CCC(c2noc(-c3ccccc3C(F)(F)F)n2)CC1
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InChI
InChI=1S/C23H18F4N6O4S2/c24-17-11-14(5-6-18(17)39(35,36)32-22-28-12-29-38-22)21(34)33-9-7-13(8-10-33)19-30-20(37-31-19)15-3-1-2-4-16(15)23(25,26)27/h1-6,11-13H,7-10H2,(H,28,29,32)
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InChIKey
MKEMCLJJOPTIGA-UHFFFAOYSA-N
Physicochemical Property
logP
4.5666
Rotatable Bonds
6
Heavy Atom Count
39
Polar Areas
131.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145992585
ChEMBL ID
CHEMBL4284471
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03042, Sodium channel protein type 3 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1955 nM
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