General Information of the Compound
Compound ID
CP0887499
Compound Name
US8952128, 42
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Structure
Formula
C89H115FN18O13S
Molecular Weight
1696.077
Canonical SMILES
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](NC[C@H](Cc2ccc(O)cc2)NC(=O)CCN(C[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)S(C)(=O)=O)CCCCNC(=O)[C@H](Cc2ccc(F)cc2)NC1=O
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InChI
InChI=1S/C89H115FN18O13S/c1-54(109)80-88(119)105-73(46-58-29-33-62(90)34-30-58)81(112)94-39-15-13-25-70(98-51-63(42-57-31-35-64(110)36-32-57)99-78(111)37-41-108(122(3,120)121)53-59-43-67-66-23-16-27-69-79(66)61(50-97-69)48-77(67)107(2)52-59)82(113)100-72(28-17-40-95-89(92)93)83(114)102-74(44-55-18-6-4-7-19-55)85(116)103-75(45-56-20-8-5-9-21-56)86(117)104-76(47-60-49-96-68-24-11-10-22-65(60)68)87(118)101-71(84(115)106-80)26-12-14-38-91/h4-11,16,18-24,27,29-36,49-50,54,59,63,67,70-77,80,96-98,109-110H,12-15,17,25-26,28,37-48,51-53,91H2,1-3H3,(H,94,112)(H,99,111)(H,100,113)(H,101,118)(H,102,114)(H,103,116)(H,104,117)(H,105,119)(H,106,115)(H4,92,93,95)/t54-,59-,63+,67-,70-,71+,72+,73+,74+,75+,76-,77-,80+/m1/s1
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InChIKey
DOQJOKJRAOIOAY-PGHFLLIESA-N
Physicochemical Property
logP
3.22887
Rotatable Bonds
29
Heavy Atom Count
122
Polar Areas
474.51
Hydrogen Bond Donor Count
18
Hydrogen Bond Acceptor Count
17
Complexity
122

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 91809318
ChEMBL ID
CHEMBL3650454
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 285.3 nM
   TI
   LI
   LO
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