General Information of the Compound
Compound ID
CP0882941
Compound Name
6,8-bis((4-methoxybenzamido)methyl)-5,7-dimethyl-2,3-dihydro-1H-indolizinium chloride
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Structure
Formula
C28H32ClN3O4
Molecular Weight
510.034
Canonical SMILES
COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1.[Cl-]
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InChI
InChI=1S/C28H31N3O4.ClH/c1-18-24(16-29-27(32)20-7-11-22(34-3)12-8-20)19(2)31-15-5-6-26(31)25(18)17-30-28(33)21-9-13-23(35-4)14-10-21;/h7-14H,5-6,15-17H2,1-4H3,(H-,29,30,32,33);1H
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InChIKey
HFCAZXREXWMNBQ-UHFFFAOYSA-N
Physicochemical Property
logP
0.41834
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
80.54
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122185634
ChEMBL ID
CHEMBL3604309
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000116 MOLT-4 Homo sapiens (Human)  1
1
IC50 = 69000 nM
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   LI
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000048 PC-3 Homo sapiens (Human)  1
1
IC50 = 153900 nM
   TI
   LI
   LO
   TS