General Information of the Compound
Compound ID
CP0882344
Compound Name
(4S)-5-[[2-[[(1S,2R)-1-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S,2S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-3-amino-1-[[2-[[2-[(2S)-2-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-1-[[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-4-oxo-butyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-hydroxy-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]carbamoyl]-3-methyl-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-2-methyl-butyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-2-methyl-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-2-oxo-ethyl]amino]-4-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-5-oxo-pentanoic acid
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Structure
Formula
C191H296N56O61S
Molecular Weight
4384.867
Canonical SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O
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InChI
InChI=1S/C191H296N56O61S/c1-16-96(10)151(185(305)228-121(55-62-148(271)272)170(290)234-129(77-104-81-209-109-38-24-23-37-107(104)109)175(295)231-124(71-92(2)3)172(292)218-111(40-26-28-65-193)164(284)235-130(79-139(197)258)159(279)212-83-140(259)210-86-143(262)247-69-32-44-136(247)183(303)240-133(88-249)181(301)239-135(90-251)182(302)246-153(99(13)253)187(307)227-113(42-30-67-207-190(201)202)162(282)221-116(49-56-137(195)256)166(286)217-112(41-29-66-206-189(199)200)163(283)229-123(155(198)275)74-103-45-47-106(255)48-46-103)244-177(297)127(75-101-33-19-17-20-34-101)233-173(293)125(72-93(4)5)230-165(285)114(43-31-68-208-191(203)204)226-184(304)150(95(8)9)243-156(276)97(11)215-160(280)118(52-59-145(265)266)222-168(288)119(53-60-146(267)268)223-169(289)120(54-61-147(269)270)224-171(291)122(63-70-309-15)225-167(287)117(50-57-138(196)257)220-161(281)110(39-25-27-64-192)219-179(299)132(87-248)238-174(294)126(73-94(6)7)232-176(296)131(80-149(273)274)236-180(300)134(89-250)241-188(308)154(100(14)254)245-178(298)128(76-102-35-21-18-22-36-102)237-186(306)152(98(12)252)242-142(261)85-213-158(278)115(51-58-144(263)264)216-141(260)84-211-157(277)108(194)78-105-82-205-91-214-105/h17-24,33-38,45-48,81-82,91-100,108,110-136,150-154,209,248-255H,16,25-32,39-44,49-80,83-90,192-194H2,1-15H3,(H2,195,256)(H2,196,257)(H2,197,258)(H2,198,275)(H,205,214)(H,210,259)(H,211,277)(H,212,279)(H,213,278)(H,215,280)(H,216,260)(H,217,286)(H,218,292)(H,219,299)(H,220,281)(H,221,282)(H,222,288)(H,223,289)(H,224,291)(H,225,287)(H,226,304)(H,227,307)(H,228,305)(H,229,283)(H,230,285)(H,231,295)(H,232,296)(H,233,293)(H,234,290)(H,235,284)(H,236,300)(H,237,306)(H,238,294)(H,239,301)(H,240,303)(H,241,308)(H,242,261)(H,243,276)(H,244,297)(H,245,298)(H,246,302)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H4,199,200,206)(H4,201,202,207)(H4,203,204,208)/t96-,97-,98+,99+,100+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,150-,151-,152-,153-,154-/m0/s1
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InChIKey
SDQPWENSCDPIGR-HJRQUUCWSA-N
Physicochemical Property
logP
-22.13019
Rotatable Bonds
148
Heavy Atom Count
309
Polar Areas
1934.14
Hydrogen Bond Donor Count
68
Hydrogen Bond Acceptor Count
63
Complexity
309

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 162673123
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01356, Glucagon-like peptide 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 0.08 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 7.13 nM
   TI
   LI
   LO
   TS
Protein ID: PT01611, Neuropeptide Y receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 300 nM
   TI
   LI
   LO
   TS