General Information of the Compound
Compound ID
CP0880929
Compound Name
1-(5-chloro-2-isobutoxybenzyl)-5-methyl-N-(4-((methylamino)methyl)phenyl)-1H-pyrazole-3-carboxamide hydrochloride
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Structure
Formula
C24H30Cl2N4O2
Molecular Weight
477.436
Canonical SMILES
CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1.Cl
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InChI
InChI=1S/C24H29ClN4O2.ClH/c1-16(2)15-31-23-10-7-20(25)12-19(23)14-29-17(3)11-22(28-29)24(30)27-21-8-5-18(6-9-21)13-26-4;/h5-12,16,26H,13-15H2,1-4H3,(H,27,30);1H
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InChIKey
NWDCTHGBQQCMAC-UHFFFAOYSA-N
Physicochemical Property
logP
5.32152
Rotatable Bonds
9
Heavy Atom Count
32
Polar Areas
68.18
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44568702
ChEMBL ID
CHEMBL492237
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01205, Prostaglandin E2 receptor EP1 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 7.943 nM
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2
Ki = 79.43 nM
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