General Information of the Compound
Compound ID
CP0880587
Compound Name
2-amino-N-(5-bromo-2-methoxy-4-((3-methyl-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)thiazole-4-sulfonamide
    Show/Hide
Structure
Formula
C15H13BrN4O5S3
Molecular Weight
505.397
Canonical SMILES
COc1cc(/C=C2\SC(=O)N(C)C2=O)c(Br)cc1NS(=O)(=O)c1csc(N)n1
    Show/Hide
InChI
InChI=1S/C15H13BrN4O5S3/c1-20-13(21)11(27-15(20)22)4-7-3-10(25-2)9(5-8(7)16)19-28(23,24)12-6-26-14(17)18-12/h3-6,19H,1-2H3,(H2,17,18)/b11-4-
    Show/Hide
InChIKey
KOFXEFYJGOGEEP-WCIBSUBMSA-N
Physicochemical Property
logP
2.9633
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
131.69
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 140897196
ChEMBL ID
CHEMBL4469497
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05581, Cyclic GMP-AMP synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 <= 2500 nM
   TI
   LI
   LO
   TS