General Information of the Compound
Compound ID
CP0859697
Compound Name
N-(5-bromo-2-methoxy-4-((3-methyl-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)pyridine-2-sulfonamide
    Show/Hide
Structure
Formula
C17H14BrN3O5S2
Molecular Weight
484.353
Canonical SMILES
COc1cc(/C=C2\SC(=O)N(C)C2=O)c(Br)cc1NS(=O)(=O)c1ccccn1
    Show/Hide
InChI
InChI=1S/C17H14BrN3O5S2/c1-21-16(22)14(27-17(21)23)8-10-7-13(26-2)12(9-11(10)18)20-28(24,25)15-5-3-4-6-19-15/h3-9,20H,1-2H3/b14-8-
    Show/Hide
InChIKey
TZCOITSFWDMHEB-ZSOIEALJSA-N
Physicochemical Property
logP
3.3196
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
105.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 140896987
ChEMBL ID
CHEMBL4520745
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05581, Cyclic GMP-AMP synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS