General Information of the Compound
Compound ID
CP0853493
Compound Name
1-((3S,10R,13S,17R)-3,17-Dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethanone oxime
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Structure
Formula
C21H33NO3
Molecular Weight
347.499
Canonical SMILES
C/C(=N/O)[C@@]1(O)CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C
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InChI
InChI=1S/C21H33NO3/c1-13(22-25)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-25H,5-12H2,1-3H3/b22-13-/t15-,16+,17-,18-,19-,20-,21-/m0/s1
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InChIKey
APPUXDKAIYXQHD-YMXNQFANSA-N
Physicochemical Property
logP
3.8913
Rotatable Bonds
1
Heavy Atom Count
25
Polar Areas
73.05
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71454452
ChEMBL ID
CHEMBL2112281
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01584, Steroid 17-alpha-hydroxylase/17,20 lyase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 12050 nM
   TI
   LI
   LO
   TS