General Information of the Compound
Compound ID
CP0851723
Compound Name
rac-2-(4-chloro-2-fluorophenoxy)-3-(4-chlorophenyl)propanoic acid
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Structure
Formula
C15H11Cl2FO3
Molecular Weight
329.154
Canonical SMILES
O=C(O)C(Cc1ccc(Cl)cc1)Oc1ccc(Cl)cc1F
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InChI
InChI=1S/C15H11Cl2FO3/c16-10-3-1-9(2-4-10)7-14(15(19)20)21-13-6-5-11(17)8-12(13)18/h1-6,8,14H,7H2,(H,19,20)
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InChIKey
YAQRTSUWRLFVKP-UHFFFAOYSA-N
Physicochemical Property
logP
4.2072
Rotatable Bonds
5
Heavy Atom Count
21
Polar Areas
46.53
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57399208
ChEMBL ID
CHEMBL1956363
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS