General Information of the Compound
Compound ID
CP0779679
Compound Name
(E)-2-Cyano-N-{3-[(E)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-acryloylamino]-propyl}-3-(3,4-dihydroxy-5-nitro-phenyl)-acrylamide
    Show/Hide
Structure
Formula
C23H18N6O10
Molecular Weight
538.429
Canonical SMILES
N#C/C(=C\c1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)NCCCNC(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1
    Show/Hide
InChI
InChI=1S/C23H18N6O10/c24-10-14(4-12-6-16(28(36)37)20(32)18(30)8-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-7-17(29(38)39)21(33)19(31)9-13/h4-9,30-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+
    Show/Hide
InChIKey
ACNOKHXCQQGNOV-VHUAAIQRSA-N
Physicochemical Property
logP
1.46206
Rotatable Bonds
10
Heavy Atom Count
39
Polar Areas
272.98
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
12
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 6082393
SID: 15781281
ChEMBL ID
CHEMBL144632
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000185 HER14 Mus musculus (Mouse)  1
1
IC50 = 35000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 > 100000 nM