General Information of the Compound
Compound ID
CP0767889
Compound Name
2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-methylbutanamide
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Structure
Formula
C25H30N4O2
Molecular Weight
418.541
Canonical SMILES
C=CC(=O)N1CC=C(c2ccc(C(C(=O)Nc3cc(C4CC4)[nH]n3)C(C)C)cc2)CC1
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InChI
InChI=1S/C25H30N4O2/c1-4-23(30)29-13-11-18(12-14-29)17-5-9-20(10-6-17)24(16(2)3)25(31)26-22-15-21(27-28-22)19-7-8-19/h4-6,9-11,15-16,19,24H,1,7-8,12-14H2,2-3H3,(H2,26,27,28,31)
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InChIKey
YDOXNEJDOWIWSE-UHFFFAOYSA-N
Physicochemical Property
logP
4.4671
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
78.09
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 139558809
ChEMBL ID
CHEMBL4799698
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04296, Cyclin-dependent kinase 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd > 100 nM
   TI
   LI
   LO
   TS