General Information of the Compound
Compound ID
CP0702760
Compound Name
(S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4-(dimethylamino)but-2-enoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)propanamide
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Structure
Formula
C26H33N5O2
Molecular Weight
447.583
Canonical SMILES
C[C@H](C(=O)Nc1cc(C2CC2)[nH]n1)c1ccc(C2=CCN(C(=O)/C=C/CN(C)C)CC2)cc1
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InChI
InChI=1S/C26H33N5O2/c1-18(26(33)27-24-17-23(28-29-24)22-10-11-22)19-6-8-20(9-7-19)21-12-15-31(16-13-21)25(32)5-4-14-30(2)3/h4-9,12,17-18,22H,10-11,13-16H2,1-3H3,(H2,27,28,29,33)/b5-4+/t18-/m0/s1
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InChIKey
IEVJHGZSBPGTMO-WRFKIARRSA-N
Physicochemical Property
logP
3.7628
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
81.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 139558793
ChEMBL ID
CHEMBL4787409
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04296, Cyclin-dependent kinase 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd < 25 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 235 nM