General Information of the Compound
Compound ID
CP0700327
Compound Name
US9045524, 88
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Structure
Formula
C34H41N5O11S
Molecular Weight
727.793
Canonical SMILES
CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O
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InChI
InChI=1S/C34H41N5O11S/c1-20(2)30(33(46)36-23(16-28(40)41)13-14-51(3,48)49)39-32(45)26(15-22-18-35-25-12-8-7-11-24(22)25)37-31(44)27(17-29(42)43)38-34(47)50-19-21-9-5-4-6-10-21/h4-14,18,20,23,26-27,30,35H,15-17,19H2,1-3H3,(H,36,46)(H,37,44)(H,38,47)(H,39,45)(H,40,41)(H,42,43)/b14-13+/t23-,26+,27+,30+/m1/s1
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InChIKey
VFANYHPZKZVWGL-ISGROHLWSA-N
Physicochemical Property
logP
1.6235
Rotatable Bonds
18
Heavy Atom Count
51
Polar Areas
250.16
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
9
Complexity
51

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44520167
SID: 85855476
ChEMBL ID
CHEMBL3678069
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01014, Caspase-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS