General Information of the Compound
Compound ID
CP0659636
Compound Name
cyclizine
    Show/Hide
Synonyms
(+-)-1-diphenylmethyl-4-methylpiperazine
(-)-1-Diphenylmethyl-4-methylpiperazine
(N-Benzhydryl)(N'-methyl)diethylenediamine
1-(Diphenylmethyl)-4-methylpiperazine
1-Benzhydryl-4-methylpiperazin
1-Benzhydryl-4-methylpiperazine
1-Diphenylmethyl-4-methylpiperazine
BW 47-83
Ciclizina
Ciclizina [INN-Spanish]
Cyclizine
Cyclizine (INN)
Cyclizine [INN:BAN:DCF]
Cyclizine chloride
Cyclizine hydrochloride
Cyclizinum
Cyclizinum [INN-Latin]
Emoquil
Emoquil (TN)
Marezine
Marezine (TN)
Marezine hydrochloride
Marzine (TN)
N-Benzhydryl-N'-methylpiperazine
N-Methyl-N'-benzhydrylpiperazine
N-Methyl-N'-benzyhydrylpiperazine
Nautazine
Ne-devomit
Neo-devomit
Reis-fit
Valoid
Valoid (TN)
Wellcome
Wellcome preparation 47-83
Wellcome prepn 47-83
Wellcome prepn. 47-83
    Show/Hide
Structure
Formula
C18H22N2
Molecular Weight
266.388
Canonical SMILES
CN1CCN(C(c2ccccc2)c2ccccc2)CC1
    Show/Hide
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
    Show/Hide
InChIKey
UVKZSORBKUEBAZ-UHFFFAOYSA-N
CAS
82-92-8
Physicochemical Property
logP
3.0234
Rotatable Bonds
3
Heavy Atom Count
20
Polar Areas
6.48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 6726
SID: 15197232
ChEMBL ID
CHEMBL648
DrugBank ID
DB01176
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00817, Cytochrome P450 2D6
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4
 Cell Line Info 
Trichoplusia ni (Cabbage looper)  1
1
IC50 = 6217.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 Potency = 7943.3 nM
Clinical Information about the Compound
Drug 1 ( Cyclizine )
Drug Name Cyclizine
Company Seatrace Pharmaceuticals
Indication
Nausea
Approved
Target(s)
Histamine H1 receptor (H1R)
 Target Info 
Antagonist