General Information of the Compound
Compound ID
CP0577538
Compound Name
5-[[(1-benzyl-5-ethylbenzimidazol-2-yl)amino]methyl]furan-2-carbonitrile
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Structure
Formula
C22H20N4O
Molecular Weight
356.429
Canonical SMILES
CCc1ccc2n(Cc3ccccc3)c(NCc3ccc(o3)C#N)nc2c1
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InChI
InChI=1S/C22H20N4O/c1-2-16-8-11-21-20(12-16)25-22(24-14-19-10-9-18(13-23)27-19)26(21)15-17-6-4-3-5-7-17/h3-12H,2,14-15H2,1H3,(H,24,25)
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InChIKey
VNWUTINXMLGHRR-UHFFFAOYSA-N
Physicochemical Property
logP
4.72378
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
66.78
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168283874
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05452, Short transient receptor potential channel 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 10000 nM
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