General Information of the Compound
Compound ID
CP0576172
Compound Name
US9150546, I-240
    Show/Hide
Structure
Formula
C25H22Cl2N4O3
Molecular Weight
497.382
Canonical SMILES
CC(C)n1c(=O)nc(Nc2ccc(Oc3ccccc3)c(Cl)c2)n(Cc2ccc(Cl)cc2)c1=O
    Show/Hide
InChI
InChI=1S/C25H22Cl2N4O3/c1-16(2)31-24(32)29-23(30(25(31)33)15-17-8-10-18(26)11-9-17)28-19-12-13-22(21(27)14-19)34-20-6-4-3-5-7-20/h3-14,16H,15H2,1-2H3,(H,28,29,32)
    Show/Hide
InChIKey
NFSZOFAKVQXYIY-UHFFFAOYSA-N
Physicochemical Property
logP
5.8769
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
78.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 58578574
ChEMBL ID
CHEMBL3890959
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000093 C6-BU-1 Rattus norvegicus (Rat)  1
1
IC50 = 953 nM
   TI
   LI
   LO
   TS