General Information of the Compound
Compound ID
CP0576030
Compound Name
3-[4-[(2,5-difluorophenyl)methyl]piperazin-1-yl]-N-(4-methyl-1,3-benzothiazol-2-yl)propanamide
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Structure
Formula
C22H24F2N4OS
Molecular Weight
430.524
Canonical SMILES
Cc1cccc2sc(NC(=O)CCN3CCN(Cc4cc(F)ccc4F)CC3)nc12
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InChI
InChI=1S/C22H24F2N4OS/c1-15-3-2-4-19-21(15)26-22(30-19)25-20(29)7-8-27-9-11-28(12-10-27)14-16-13-17(23)5-6-18(16)24/h2-6,13H,7-12,14H2,1H3,(H,25,26,29)
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InChIKey
KEEWNRZJJWZGPB-UHFFFAOYSA-N
Physicochemical Property
logP
4.02932
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
48.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168288341
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02751, Glutamate receptor ionotropic, NMDA 2B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000101 L-M(TK-) Mus musculus (Mouse)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS