General Information of the Compound
Compound ID
CP0575342
Compound Name
N,N-dimethyl-2-[4-[4-(1-methyl-6-oxopyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl]acetamide
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Structure
Formula
C22H27N5O2
Molecular Weight
393.491
Canonical SMILES
CN(C)C(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1ccc(=O)n(C)c1
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InChI
InChI=1S/C22H27N5O2/c1-25(2)21(29)14-27-10-7-15(8-11-27)19-12-18-17(6-9-23-22(18)24-19)16-4-5-20(28)26(3)13-16/h4-6,9,12-13,15H,7-8,10-11,14H2,1-3H3,(H,23,24)
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InChIKey
FFKPECRVCCCIST-UHFFFAOYSA-N
Physicochemical Property
logP
2.1962
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
74.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168296830
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01235, Cyclin-dependent kinase 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  1
1
IC50 > 3000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM
2 IC50 = 1000 nM