General Information of the Compound
Compound ID
CP0575189
Compound Name
2-chloro-6-[[4-(1,3,4-oxadiazol-2-yl)phenoxy]methyl]benzonitrile
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Structure
Formula
C16H10ClN3O2
Molecular Weight
311.728
Canonical SMILES
Clc1cccc(COc2ccc(cc2)-c2nnco2)c1C#N
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InChI
InChI=1S/C16H10ClN3O2/c17-15-3-1-2-12(14(15)8-18)9-21-13-6-4-11(5-7-13)16-20-19-10-22-16/h1-7,10H,9H2
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InChIKey
HJOHAUCZPLKYSW-UHFFFAOYSA-N
Physicochemical Property
logP
3.84068
Rotatable Bonds
4
Heavy Atom Count
22
Polar Areas
71.94
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155512391
ChEMBL ID
CHEMBL4437017
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02546, Toll-like receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2520 nM
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