General Information of the Compound
Compound ID
CP0573913
Compound Name
1-[[4-(propylamino)pyrazol-1-yl]methyl]-N-[4-(trifluoromethyl)phenyl]pyrazole-3-carboxamide
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Formula
C18H19F3N6O
Molecular Weight
392.385
Canonical SMILES
CCCNc1cnn(Cn2ccc(n2)C(=O)Nc2ccc(cc2)C(F)(F)F)c1
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InChI
InChI=1S/C18H19F3N6O/c1-2-8-22-15-10-23-27(11-15)12-26-9-7-16(25-26)17(28)24-14-5-3-13(4-6-14)18(19,20)21/h3-7,9-11,22H,2,8,12H2,1H3,(H,24,28)
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InChIKey
HHXKFEOBTAANKG-UHFFFAOYSA-N
Physicochemical Property
logP
3.6784
Rotatable Bonds
7
Heavy Atom Count
28
Polar Areas
76.77
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4876055
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02791, Hypoxia-inducible factor 1-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 1200 nM
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