General Information of the Compound
Compound ID
CP0573906
Compound Name
1-(2,2-dimethylpropyl)-3-[1-[[4-(methoxymethoxy)phenyl]methyl]-2,3-dihydroindol-5-yl]thiourea
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Structure
Formula
C23H31N3O2S
Molecular Weight
413.587
Canonical SMILES
COCOc1ccc(CN2CCc3cc(NC(=S)NCC(C)(C)C)ccc23)cc1
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InChI
InChI=1S/C23H31N3O2S/c1-23(2,3)15-24-22(29)25-19-7-10-21-18(13-19)11-12-26(21)14-17-5-8-20(9-6-17)28-16-27-4/h5-10,13H,11-12,14-16H2,1-4H3,(H2,24,25,29)
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InChIKey
FSUNZGRBBQCVRF-UHFFFAOYSA-N
Physicochemical Property
logP
4.5645
Rotatable Bonds
7
Heavy Atom Count
29
Polar Areas
45.76
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168297252
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01242, Polyunsaturated fatty acid 5-lipoxygenase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000831 PMNL Homo sapiens (Human)  1
1
IC50 = 2930 nM
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