General Information of the Compound
Compound ID
CP0573879
Compound Name
N-[[5,7-dimethyl-8-[[(4-methylsulfanylbenzoyl)amino]methyl]-2,3-dihydro-1H-indolizin-4-ium-6-yl]methyl]-4-methylsulfanylbenzamide;chloride
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Structure
Formula
C28H32ClN3O2S2
Molecular Weight
542.17
Canonical SMILES
[Cl-].CSc1ccc(cc1)C(=O)NCc1c2CCC[n+]2c(C)c(CNC(=O)c2ccc(SC)cc2)c1C
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InChI
InChI=1S/C28H31N3O2S2.ClH/c1-18-24(16-29-27(32)20-7-11-22(34-3)12-8-20)19(2)31-15-5-6-26(31)25(18)17-30-28(33)21-9-13-23(35-4)14-10-21;/h7-14H,5-6,15-17H2,1-4H3,(H-,29,30,32,33);1H
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InChIKey
KDQWIIKQMXSILQ-UHFFFAOYSA-N
Physicochemical Property
logP
1.84494
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
62.08
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122185632
ChEMBL ID
CHEMBL3604308
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000116 MOLT-4 Homo sapiens (Human)  1
1
IC50 = 19300 nM
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