General Information of the Compound
Compound ID
CP0572527
Compound Name
4-(3,5-dimethylpyrazol-1-yl)-N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]benzenesulfonamide
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Structure
Formula
C29H25N5O3S2
Molecular Weight
555.685
Canonical SMILES
CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(cc2)-n2nc(C)cc2C)c1
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InChI
InChI=1S/C29H25N5O3S2/c1-18-12-19(2)34(31-18)24-5-7-25(8-6-24)39(36,37)32-23-14-21(15-30-16-23)28-11-10-27(38-28)20-4-9-26-22(13-20)17-33(3)29(26)35/h4-16,32H,17H2,1-3H3
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InChIKey
UHITYSUIBZMORF-UHFFFAOYSA-N
Physicochemical Property
logP
5.66604
Rotatable Bonds
6
Heavy Atom Count
39
Polar Areas
97.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73296861
ChEMBL ID
CHEMBL4168872
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 19100 nM
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