General Information of the Compound
Compound ID
CP0571093
Compound Name
1-[(3S)-4-[(7S)-7-(3-hydroxynaphthalen-1-yl)-2-[(1-methylimidazol-4-yl)methoxy]-5,6,7,8-tetrahydroquinazolin-4-yl]-3-methylpiperazin-1-yl]prop-2-en-1-one
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Structure
Formula
C31H34N6O3
Molecular Weight
538.652
Canonical SMILES
C[C@H]1CN(CCN1c1nc(OCc2cn(C)cn2)nc2C[C@H](CCc12)c1cc(O)cc2ccccc12)C(=O)C=C
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InChI
InChI=1S/C31H34N6O3/c1-4-29(39)36-11-12-37(20(2)16-36)30-26-10-9-22(27-15-24(38)13-21-7-5-6-8-25(21)27)14-28(26)33-31(34-30)40-18-23-17-35(3)19-32-23/h4-8,13,15,17,19-20,22,38H,1,9-12,14,16,18H2,2-3H3/t20-,22-/m0/s1
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InChIKey
WRRIEBSQCWUQBF-UNMCSNQZSA-N
Physicochemical Property
logP
4.1435
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
96.61
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166627537
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000705 HCC1171 Homo sapiens (Human)  1
1
EC50 = 3000 nM
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