General Information of the Compound
Compound ID
CP0570270
Compound Name
3-chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-2-methyl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]pyrrole-2,5-dione
    Show/Hide
Structure
Formula
C19H13ClF4N4O3
Molecular Weight
456.783
Canonical SMILES
Cc1nc2CN(CCc2c(Oc2ccc(F)cc2C(F)(F)F)n1)C1=C(Cl)C(=O)NC1=O
    Show/Hide
InChI
InChI=1S/C19H13ClF4N4O3/c1-8-25-12-7-28(15-14(20)16(29)27-17(15)30)5-4-10(12)18(26-8)31-13-3-2-9(21)6-11(13)19(22,23)24/h2-3,6H,4-5,7H2,1H3,(H,27,29,30)
    Show/Hide
InChIKey
DPATUHNUTTZBBN-UHFFFAOYSA-N
Physicochemical Property
logP
3.20012
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
84.42
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 168281098
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05452, Short transient receptor potential channel 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 125 nM
   TI
   LI
   LO
   TS