General Information of the Compound
Compound ID
CP0568984
Compound Name
3-(1-benzylpiperidin-4-yl)-1-[4-[4-[4-(1H-indol-3-yl)butyl]piperazin-1-yl]phenyl]propan-1-one
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Structure
Formula
C37H46N4O
Molecular Weight
562.802
Canonical SMILES
O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccccc23)CC1
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InChI
InChI=1S/C37H46N4O/c42-37(18-13-30-19-22-40(23-20-30)29-31-8-2-1-3-9-31)32-14-16-34(17-15-32)41-26-24-39(25-27-41)21-7-6-10-33-28-38-36-12-5-4-11-35(33)36/h1-5,8-9,11-12,14-17,28,30,38H,6-7,10,13,18-27,29H2
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InChIKey
AEUPTFPGPNPFKY-UHFFFAOYSA-N
Physicochemical Property
logP
7.1879
Rotatable Bonds
12
Heavy Atom Count
42
Polar Areas
42.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166627011
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 334 nM
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Protein ID: PT00871, Sodium-dependent serotonin transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 284.55 nM
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   LI
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