General Information of the Compound
Compound ID
CP0564181
Compound Name
3-[4-[(4-amino-1-bicyclo[2.2.2]octanyl)methoxy]-3-fluorophenyl]-1-methylpyrazolo[3,4-d]pyrimidin-6-amine
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Structure
Formula
C21H25FN6O
Molecular Weight
396.47
Canonical SMILES
Cn1nc(-c2ccc(OCC34CCC(N)(CC3)CC4)c(F)c2)c2cnc(N)nc12
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InChI
InChI=1S/C21H25FN6O/c1-28-18-14(11-25-19(23)26-18)17(27-28)13-2-3-16(15(22)10-13)29-12-20-4-7-21(24,8-5-20)9-6-20/h2-3,10-11H,4-9,12,24H2,1H3,(H2,23,25,26)
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InChIKey
JGBLHVKRSBVZJG-UHFFFAOYSA-N
Physicochemical Property
logP
3.1821
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
104.87
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 129073171
ChEMBL ID
CHEMBL4748638
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02546, Toll-like receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 3 nM
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