General Information of the Compound
Compound ID
CP0560321
Compound Name
2-bromo-N-(3-phenylpropyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-6-amine
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Structure
Formula
C18H22BrNS
Molecular Weight
364.352
Canonical SMILES
Brc1cc2CCC(CCc2s1)NCCCc1ccccc1
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InChI
InChI=1S/C18H22BrNS/c19-18-13-15-8-9-16(10-11-17(15)21-18)20-12-4-7-14-5-2-1-3-6-14/h1-3,5-6,13,16,20H,4,7-12H2
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InChIKey
COEFOOWNWLEYHU-UHFFFAOYSA-N
Physicochemical Property
logP
4.9804
Rotatable Bonds
5
Heavy Atom Count
21
Polar Areas
12.03
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156009947
ChEMBL ID
CHEMBL4632765
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02751, Glutamate receptor ionotropic, NMDA 2B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000101 L-M(TK-) Mus musculus (Mouse)  1
1
Ki = 13 nM
   TI
   LI
   LO
   TS