General Information of the Compound
Compound ID
CP0559425
Compound Name
N-(2,5-dichlorophenyl)-2-methyl-5-oxo-4-(2-pyrazol-1-ylethyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
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Structure
Formula
C22H22Cl2N4O2
Molecular Weight
445.35
Canonical SMILES
CC1=C(C(CCn2cccn2)C2=C(CCCC2=O)N1)C(=O)Nc1cc(Cl)ccc1Cl
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InChI
InChI=1S/C22H22Cl2N4O2/c1-13-20(22(30)27-18-12-14(23)6-7-16(18)24)15(8-11-28-10-3-9-25-28)21-17(26-13)4-2-5-19(21)29/h3,6-7,9-10,12,15,26H,2,4-5,8,11H2,1H3,(H,27,30)
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InChIKey
XKPDMKYPTHXBMT-UHFFFAOYSA-N
Physicochemical Property
logP
4.7192
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
76.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155535425
ChEMBL ID
CHEMBL4472390
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03133, Free fatty acid receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000460 Flp-In-T-REx-293 Homo sapiens (Human)  1
1
EC50 = 11220.18 nM
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