General Information of the Compound
Compound ID
CP0559223
Compound Name
2-methoxy-N-[3-[2-[(3-methylbenzoyl)amino]ethylamino]phenyl]-5-[3-[methyl(pyridin-4-ylmethyl)carbamoyl]phenyl]benzamide
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Structure
Formula
C38H37N5O4
Molecular Weight
627.745
Canonical SMILES
COc1ccc(cc1C(=O)Nc1cccc(NCCNC(=O)c2cccc(C)c2)c1)-c1cccc(c1)C(=O)N(C)Cc1ccncc1
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InChI
InChI=1S/C38H37N5O4/c1-26-7-4-9-30(21-26)36(44)41-20-19-40-32-11-6-12-33(24-32)42-37(45)34-23-29(13-14-35(34)47-3)28-8-5-10-31(22-28)38(46)43(2)25-27-15-17-39-18-16-27/h4-18,21-24,40H,19-20,25H2,1-3H3,(H,41,44)(H,42,45)
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InChIKey
TWAJJKNZPTXWJK-UHFFFAOYSA-N
Physicochemical Property
logP
6.43202
Rotatable Bonds
12
Heavy Atom Count
47
Polar Areas
112.66
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166633946
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01132, Orexin receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000076 CHO/Galpha16 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 863 nM
   TI
   LI
   LO
   TS
Protein ID: PT02001, Orexin/Hypocretin receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000076 CHO/Galpha16 Cricetulus griseus (Chinese hamster)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS