General Information of the Compound
Compound ID
CP0558730
Compound Name
6-chloro-4-N-[1-[(2-fluorophenyl)methyl]piperidin-4-yl]pyrimidine-2,4-diamine
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Structure
Formula
C16H19ClFN5
Molecular Weight
335.814
Canonical SMILES
Nc1nc(Cl)cc(NC2CCN(Cc3ccccc3F)CC2)n1
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InChI
InChI=1S/C16H19ClFN5/c17-14-9-15(22-16(19)21-14)20-12-5-7-23(8-6-12)10-11-3-1-2-4-13(11)18/h1-4,9,12H,5-8,10H2,(H3,19,20,21,22)
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InChIKey
NIRSXJWTRGUECF-UHFFFAOYSA-N
Physicochemical Property
logP
2.9278
Rotatable Bonds
4
Heavy Atom Count
23
Polar Areas
67.07
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72153748
ChEMBL ID
CHEMBL4172964
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 100000 nM
   TI
   LI
   LO
   TS