General Information of the Compound
Compound ID
CP0558570
Compound Name
US9150546, I-434
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Structure
Formula
C21H20Cl2N4O5
Molecular Weight
479.32
Canonical SMILES
CC(C)Oc1ccc(cc1Cl)\N=c1/[nH]c(=O)n(CC(O)=O)c(=O)n1Cc1ccc(Cl)cc1
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InChI
InChI=1S/C21H20Cl2N4O5/c1-12(2)32-17-8-7-15(9-16(17)23)24-19-25-20(30)27(11-18(28)29)21(31)26(19)10-13-3-5-14(22)6-4-13/h3-9,12H,10-11H2,1-2H3,(H,28,29)(H,24,25,30)
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InChIKey
VEMXKDNCOMOECJ-UHFFFAOYSA-N
Physicochemical Property
logP
2.7974
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
118.68
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58578367
ChEMBL ID
CHEMBL3959782
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000093 C6-BU-1 Rattus norvegicus (Rat)  1
1
IC50 = 20 nM
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