General Information of the Compound
Compound ID
CP0555691
Compound Name
2-[4-[[5-(3-chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]amino]phenyl]acetic acid
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Structure
Formula
C19H18ClN3O3S
Molecular Weight
403.891
Canonical SMILES
CC(C)Oc1ccc(cc1Cl)-c1nnc(Nc2ccc(CC(O)=O)cc2)s1
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InChI
InChI=1S/C19H18ClN3O3S/c1-11(2)26-16-8-5-13(10-15(16)20)18-22-23-19(27-18)21-14-6-3-12(4-7-14)9-17(24)25/h3-8,10-11H,9H2,1-2H3,(H,21,23)(H,24,25)
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InChIKey
DFXKLYZOOCNUQG-UHFFFAOYSA-N
Physicochemical Property
logP
5.0164
Rotatable Bonds
7
Heavy Atom Count
27
Polar Areas
84.34
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127028150
ChEMBL ID
CHEMBL3769712
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01688, Sphingosine 1-phosphate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000466 McA-RH7777 Rattus norvegicus (Rat)  1
1
EC50 = 1258.93 nM
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