General Information of the Compound
Compound ID
CP0553822
Compound Name
US8987445, 61
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Structure
Formula
C29H28N2O4S
Molecular Weight
500.62
Canonical SMILES
Cc1c(ncc2ccccc12)N(Cc1ccc2c(CCC2(C)C)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
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InChI
InChI=1S/C29H28N2O4S/c1-19-25-7-5-4-6-23(25)17-30-27(19)31(36(34,35)24-11-9-21(10-12-24)28(32)33)18-20-8-13-26-22(16-20)14-15-29(26,2)3/h4-13,16-17H,14-15,18H2,1-3H3,(H,32,33)
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InChIKey
TXMQIHYKAVMTEJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.86072
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
87.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 66547949
SID: 152140466
ChEMBL ID
CHEMBL3682568
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03065, Transient receptor potential cation channel subfamily M member 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1.3 nM
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   LI
   LO
   TS