General Information of the Compound
Compound ID
CP0553249
Compound Name
2,4-difluoro-N-[5-[5-[1-oxo-2-(2-pyrrolidin-1-ylethyl)-3H-isoindol-5-yl]thiophen-2-yl]pyridin-3-yl]benzenesulfonamide
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Structure
Formula
C29H26F2N4O3S2
Molecular Weight
580.682
Canonical SMILES
Fc1ccc(c(F)c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(s1)-c1ccc2C(=O)N(CCN3CCCC3)Cc2c1
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InChI
InChI=1S/C29H26F2N4O3S2/c30-22-4-8-28(25(31)15-22)40(37,38)33-23-14-20(16-32-17-23)27-7-6-26(39-27)19-3-5-24-21(13-19)18-35(29(24)36)12-11-34-9-1-2-10-34/h3-8,13-17,33H,1-2,9-12,18H2
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InChIKey
ODALLMIFEUAEME-UHFFFAOYSA-N
Physicochemical Property
logP
5.6077
Rotatable Bonds
8
Heavy Atom Count
40
Polar Areas
82.61
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155546518
ChEMBL ID
CHEMBL4532231
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05158, Perforin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS