General Information of the Compound
Compound ID
CP0552185
Compound Name
5-amino-N-[[4-[[(2S)-4-cyclohexyl-1-morpholin-4-yl-1-oxobutan-2-yl]carbamoyl]phenyl]methyl]-1-phenylpyrazole-4-carboxamide
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Formula
C32H40N6O4
Molecular Weight
572.71
Canonical SMILES
Nc1c(cnn1-c1ccccc1)C(=O)NCc1ccc(cc1)C(=O)N[C@@H](CCC1CCCCC1)C(=O)N1CCOCC1
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InChI
InChI=1S/C32H40N6O4/c33-29-27(22-35-38(29)26-9-5-2-6-10-26)31(40)34-21-24-11-14-25(15-12-24)30(39)36-28(16-13-23-7-3-1-4-8-23)32(41)37-17-19-42-20-18-37/h2,5-6,9-12,14-15,22-23,28H,1,3-4,7-8,13,16-21,33H2,(H,34,40)(H,36,39)/t28-/m0/s1
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InChIKey
SHPDQLJRQYHHLZ-NDEPHWFRSA-N
Physicochemical Property
logP
3.7022
Rotatable Bonds
10
Heavy Atom Count
42
Polar Areas
131.58
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4796755
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00861, Mitogen-activated protein kinase 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 44.8 nM
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