General Information of the Compound
Compound ID
CP0550132
Compound Name
4-[2-(2,5-difluorophenoxy)ethylamino]-1,1-dioxo-3,4-dihydro-2H-thiochromene-6-carboxamide;hydrochloride
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Structure
Formula
C18H19ClF2N2O4S
Molecular Weight
432.876
Canonical SMILES
Cl.NC(=O)c1ccc2c(c1)C(CCS2(=O)=O)NCCOc1cc(F)ccc1F
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InChI
InChI=1S/C18H18F2N2O4S.ClH/c19-12-2-3-14(20)16(10-12)26-7-6-22-15-5-8-27(24,25)17-4-1-11(18(21)23)9-13(15)17;/h1-4,9-10,15,22H,5-8H2,(H2,21,23);1H
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InChIKey
JWFVVZAJHADOTO-UHFFFAOYSA-N
Physicochemical Property
logP
2.3726
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
98.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145965240
ChEMBL ID
CHEMBL4210948
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01004, Alpha-1D adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 86 nM
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