General Information of the Compound
Compound ID
CP0549713
Compound Name
(E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-5-phenylpent-1-en-3-one
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Structure
Formula
C19H20O4
Molecular Weight
312.365
Canonical SMILES
COc1cc(\C=C\C(=O)CCc2ccccc2)cc(OC)c1O
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InChI
InChI=1S/C19H20O4/c1-22-17-12-15(13-18(23-2)19(17)21)9-11-16(20)10-8-14-6-4-3-5-7-14/h3-7,9,11-13,21H,8,10H2,1-2H3/b11-9+
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InChIKey
CDBZHWPYXNRIIV-PKNBQFBNSA-N
Physicochemical Property
logP
3.6245
Rotatable Bonds
7
Heavy Atom Count
23
Polar Areas
55.76
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 14839270
ChEMBL ID
CHEMBL5092055
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01242, Polyunsaturated fatty acid 5-lipoxygenase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000831 PMNL Homo sapiens (Human)  1
1
IC50 = 410 nM
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