General Information of the Compound
Compound ID
CP0549042
Compound Name
6-[2-[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]-7-azaspiro[3.5]non-2-en-7-yl]quinoline-2-carboxylic acid
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Structure
Formula
C30H25Cl2N3O3
Molecular Weight
546.454
Canonical SMILES
OC(=O)c1ccc2cc(ccc2n1)N1CCC2(CC(=C2)c2c(onc2-c2c(Cl)cccc2Cl)C2CC2)CC1
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InChI
InChI=1S/C30H25Cl2N3O3/c31-21-2-1-3-22(32)26(21)27-25(28(38-34-27)17-4-5-17)19-15-30(16-19)10-12-35(13-11-30)20-7-9-23-18(14-20)6-8-24(33-23)29(36)37/h1-3,6-9,14-15,17H,4-5,10-13,16H2,(H,36,37)
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InChIKey
UXZHKRXZCXSKGC-UHFFFAOYSA-N
Physicochemical Property
logP
7.8461
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
79.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 138591976
ChEMBL ID
CHEMBL4872481
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 63 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 415 nM