General Information of the Compound
Compound ID
CP0547306
Compound Name
(2S)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-aminopropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-[[4-(2-phenylethynyl)phenyl]methyl]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
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Structure
Formula
C55H67N9O10S2
Molecular Weight
1078.328
Canonical SMILES
CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(cc2)C#Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O
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InChI
InChI=1S/C55H67N9O10S2/c1-33(2)47(55(73)74)64-54(72)46-32-76-75-31-45(62-48(66)34(3)57)53(71)61-42(28-37-14-8-5-9-15-37)51(69)60-43(29-38-21-19-36(20-22-38)18-17-35-12-6-4-7-13-35)50(68)58-41(16-10-11-27-56)49(67)59-44(52(70)63-46)30-39-23-25-40(65)26-24-39/h4-9,12-15,19-26,33-34,41-47,65H,10-11,16,27-32,56-57H2,1-3H3,(H,58,68)(H,59,67)(H,60,69)(H,61,71)(H,62,66)(H,63,70)(H,64,72)(H,73,74)/t34-,41-,42-,43+,44-,45-,46-,47-/m0/s1
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InChIKey
GQCLMONRXRUOPI-HEEMNDMOSA-N
Physicochemical Property
logP
1.8253
Rotatable Bonds
16
Heavy Atom Count
76
Polar Areas
313.27
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
13
Complexity
76

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156017817
ChEMBL ID
CHEMBL4643905
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 12.02 nM
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