General Information of the Compound
Compound ID
CP0546369
Compound Name
7-methyl-3-[4-[[7-methyl-9,10-dioxo-5-(2-phenylethyl)-7,8-dihydro-6H-indeno[1,2-b]indol-3-yl]oxy]butoxy]-5-(2-phenylethyl)-7,8-dihydro-6H-indeno[1,2-b]indole-9,10-dione
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Formula
C52H48N2O6
Molecular Weight
796.964
Canonical SMILES
CC1Cc2c(c3C(=O)c4ccc(OCCCCOc5ccc6C(=O)c7c8c(CC(C)CC8=O)n(CCc8ccccc8)c7-c6c5)cc4-c3n2CCc2ccccc2)C(=O)C1
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InChI
InChI=1S/C52H48N2O6/c1-31-25-41-45(43(55)27-31)47-49(53(41)21-19-33-11-5-3-6-12-33)39-29-35(15-17-37(39)51(47)57)59-23-9-10-24-60-36-16-18-38-40(30-36)50-48(52(38)58)46-42(26-32(2)28-44(46)56)54(50)22-20-34-13-7-4-8-14-34/h3-8,11-18,29-32H,9-10,19-28H2,1-2H3
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InChIKey
CJEZGMNZMVCTGO-UHFFFAOYSA-N
Physicochemical Property
logP
9.9658
Rotatable Bonds
13
Heavy Atom Count
60
Polar Areas
96.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4852014
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 867 nM
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