General Information of the Compound
Compound ID
CP0546231
Compound Name
N-methyl-2-[4-[4-(6-oxo-1-propan-2-ylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl]acetamide
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Structure
Formula
C23H29N5O2
Molecular Weight
407.518
Canonical SMILES
CNC(=O)CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1ccc(=O)n(c1)C(C)C
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InChI
InChI=1S/C23H29N5O2/c1-15(2)28-13-17(4-5-22(28)30)18-6-9-25-23-19(18)12-20(26-23)16-7-10-27(11-8-16)14-21(29)24-3/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3,(H,24,29)(H,25,26)
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InChIKey
GZXWMFLENSULBI-UHFFFAOYSA-N
Physicochemical Property
logP
2.8979
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
83.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168276991
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01235, Cyclin-dependent kinase 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  1
1
IC50 = 94 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM