General Information of the Compound
Compound ID
CP0546181
Compound Name
N-[[2-chloro-4-(methanesulfonamido)phenyl]methyl]-4-(trifluoromethoxy)benzamide
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Structure
Formula
C16H14ClF3N2O4S
Molecular Weight
422.812
Canonical SMILES
CS(=O)(=O)Nc1ccc(CNC(=O)c2ccc(OC(F)(F)F)cc2)c(Cl)c1
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InChI
InChI=1S/C16H14ClF3N2O4S/c1-27(24,25)22-12-5-2-11(14(17)8-12)9-21-15(23)10-3-6-13(7-4-10)26-16(18,19)20/h2-8,22H,9H2,1H3,(H,21,23)
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InChIKey
BXJVZDVHPFAFHO-UHFFFAOYSA-N
Physicochemical Property
logP
3.5401
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
84.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166630802
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
EC50 = 1090 nM
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