General Information of the Compound
Compound ID
CP0545408
Compound Name
[4-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]piperazin-1-yl]-pyridin-2-ylmethanone
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Structure
Formula
C24H33N5O2
Molecular Weight
423.561
Canonical SMILES
COc1ccccc1N1CCN(CCCN2CCN(CC2)C(=O)c2ccccn2)CC1
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InChI
InChI=1S/C24H33N5O2/c1-31-23-9-3-2-8-22(23)28-17-13-26(14-18-28)11-6-12-27-15-19-29(20-16-27)24(30)21-7-4-5-10-25-21/h2-5,7-10H,6,11-20H2,1H3
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InChIKey
JMJMAIPPNDZPFH-UHFFFAOYSA-N
Physicochemical Property
logP
2.0603
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
52.15
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168274655
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 590 nM
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