General Information of the Compound
Compound ID
CP0540361
Compound Name
DCC-3014
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Synonyms
1628606-05-2
2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one
3-Methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-4(3H)-pyrimidinone
3-methyl-5-[6-methyl-5-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxypyridin-2-yl]-2-(propan-2-ylamino)pyrimidin-4-one
4(3H)-Pyrimidinone, 3-methyl-2-((1-methylethyl)amino)-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl)oxy)-2-pyridinyl)-
CS-0121044
DCC-3014
DCC3014
EX-A4700
GTPL11190
HY-136256
NSC-828316
NSC828316
PX9FTM69BF
SCHEMBL16047448
UNII-PX9FTM69BF
Vimseltinib
Vimseltinib [INN]
example 10 [WO2014145025A2]
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Structure
Formula
C23H25N7O2
Molecular Weight
431.5
Canonical SMILES
CC(C)Nc1ncc(-c2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)c(=O)n1C
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InChI
InChI=1S/C23H25N7O2/c1-14(2)27-23-25-12-18(22(31)30(23)5)19-6-7-21(15(3)28-19)32-17-8-9-24-20(10-17)16-11-26-29(4)13-16/h6-14H,1-5H3,(H,25,27)
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InChIKey
TVGAHWWPABTBCX-UHFFFAOYSA-N
CAS
1628606-05-2
Physicochemical Property
logP
3.55882
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
99.75
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 86267612
ChEMBL ID
CHEMBL5095202
DrugBank ID
DB17520
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01008, Macrophage colony-stimulating factor 1 receptor
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.7 nM
Clinical Information about the Compound
Drug 1 ( DCC-3014 )
Drug Name DCC-3014
Company Deciphera Pharmaceuticals
Indication
Solid tumour/cancer
Phase 1/2
Target(s)
Macrophage colony-stimulating factor 1 receptor (CSF1R)
 Target Info 
Inhibitor