General Information of the Compound
Compound ID
CP0537868
Compound Name
[3-oxo-3-[3-(pyridine-2-carbonylamino)anilino]propyl] piperidine-1-carbodithioate
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Structure
Formula
C21H24N4O2S2
Molecular Weight
428.583
Canonical SMILES
O=C(CCSC(=S)N1CCCCC1)Nc1cccc(NC(=O)c2ccccn2)c1
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InChI
InChI=1S/C21H24N4O2S2/c26-19(10-14-29-21(28)25-12-4-1-5-13-25)23-16-7-6-8-17(15-16)24-20(27)18-9-2-3-11-22-18/h2-3,6-9,11,15H,1,4-5,10,12-14H2,(H,23,26)(H,24,27)
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InChIKey
IVMJQHQQWWOXKP-UHFFFAOYSA-N
Physicochemical Property
logP
4.1665
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
74.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155516880
ChEMBL ID
CHEMBL4443510
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 113 nM
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